Effectiveness of Rocuronium bromide: An assessment
Abstract
The study focuses on succinylcholine, a commonly used muscle relaxant for pediatric patients, and rocuronium, a newer non-depolarizing muscle relaxant. The objective was to evaluate the onset time, progression, and duration of muscle relaxation, as well as tracheal intubation conditions for both drugs. This randomized, double-blind study was conducted on 50 pediatric patients aged 2 to 6 years, classified as ASA grade I and II, who underwent surgeries lasting less than 30 minutes. Patients received either intravenous rocuronium (0.9 mg/kg) or succinylcholine (1.5 mg/kg) following premedication with fentanyl (1 µg/kg) and thiopentone (5 mg/kg). Neuromuscular blockade was assessed by measuring the twitch response of the adductor pollicis longus muscle after supra-maximal stimulation of the ulnar nerve. An independent, blinded anesthetist evaluated the tracheal intubation conditions one minute after drug administration and then every 15 seconds until successful intubation. The onset time and degree of neuromuscular blockade were also recorded during the procedure.
Keywords: Neuromuscular Relaxant, Pediatric Patients, Succinylcholine, Rocuronium, TOF Guard, Intraoperative Pressure.
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